The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans
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Inhibitory Killer Cell Immunoglobulin-Like Receptor KIR3DL1 in Combination with HLA-B Bw4iso Protect against Ankylosing Spondylitis
Background: The HLA class I molecules serve as ligands for both T cell receptors and killer cell immunoglobulin-like receptors (KIRs). Objective: We investigated the HLAC and HLA-Bw4 alleles as well as KIRs expression on CD56 positive lymphocytes to evaluate whether these genes and molecules could influence Ankylosing spondylitis (AS) susceptibility, alone or in combination. Methods: We typed 4...
متن کاملinhibitory killer cell immunoglobulin-like receptor kir3dl1 in combination with hla-b bw4iso protect against ankylosing spondylitis
background: the hla class i molecules serve as ligands for both t cell receptors and killer cell immunoglobulin-like receptors (kirs). objective: we investigated the hlac and hla-bw4 alleles as well as kirs expression on cd56 positive lymphocytes to evaluate whether these genes and molecules could influence ankylosing spondylitis (as) susceptibility, alone or in combination. methods: we typed 4...
متن کاملPolymorphic sites away from the Bw4 epitope that affect interaction of Bw4+ HLA-B with KIR3DL1.
KIR3DL1 is a polymorphic, inhibitory NK cell receptor specific for the Bw4 epitope carried by subsets of HLA-A and HLA-B allotypes. The Bw4 epitope of HLA-B*5101 and HLA-B*1513 is determined by the NIALR sequence motif at positions 77, 80, 81, 82, and 83 in the alpha(1) helix. Mutation of these positions to the residues present in the alternative and nonfunctional Bw6 motif showed that the func...
متن کاملKiller cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1.
HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in the level of HIV control among B*57+ individuals. Using whole-genome sequencing of untreated B*57+ HIV-1-infected controllers and noncontrollers, we identified a single variant (rs643347A/G) encoding an isoleucine-to-valine substitution at position 47 (I47V) of the inhib...
متن کاملKiller-cell immunoglobulin-like receptor
INTRODUCTION During discussion at the WHO Nomenclature Committee for Factors of the HLA System meeting in Victoria, Canada, in May 2002, it was decided to form a subcommittee to coordinate the naming of alleles of the genes encoding the killer-cell immunoglobulin-like receptors (KIRs) [1]. These genes are encoded on chromosome 19 (19q13.4) and have varying degrees of polymorphism. The receptors...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2016
ISSN: 1466-4879,1476-5470
DOI: 10.1038/gene.2016.5